Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

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The efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis.Patients were enrolled in an open-label compassionate use program.One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activity index was ROSE ABSOLUTE assessed at baseline and on days 14 and 28.

On days 14 and 28, 78.0% and 88.1% of patients, respectively, demonstrated an improvement in disease activity index.

The mean decline in disease activity index on day 14 was 40.7% (P=0.0001) and on day 28 it was 55.

4% (P=0.0001).Efficacy was similar whether the disease was confined to or extended beyond 30 cm from the anus.

There Goalie - Cages was no difference in efficacy in patients suffering their first episode of disease compared to patients suffering subsequent attacks.In conclusion, high dose 5-ASA enemas are a highly effective treatment for distal ulcerative colitis.